Research Opportunity Number: CHE-02

Project Title: Computational Modeling and Validation of Copper-Binding Proteins and Protein Complexes 

Project Summary: Using the protein structure modeling programs AlphaFold3 and RoseTTAFold All-Atom, we seek to identify the copper-binding amino acids and the quaternary structures of copper-bound proteins and protein complexes to better understand the biophysical parameters. The predicted models will then be used to guide the structural analysis of the copper proteomics targets generated from our recent cell-based screens. These structural insights will be critical to understand how copper regulates cellular functions.

Student Roles and Responsibilities: Computer modeling, prepare proteomic samples, biochemical analysis of protein targets using computational modeling and Proteomic analysis.

Additional Considerations: Students should have completed at least a year of Chemistry, Biology and Physics by the beginning of LLP and have coding skills and lab research experience.

Department/Institute: Department of Chemistry

Participation Dates: June 12 – August 15, 2025

Stipend Offered: $0

Number of Internships Available: 0-1

Application Deadline: March 15, 2025, midnight Eastern Daylight Time