Research Opportunity Number: LSI-02

Project Title: Modeling Disease Dysregulation Using Large Genomic Datasets

Project Summary: A key challenge in biomedical science is to understand how the genome, common to all cells in the body, codes for different cell types with broadly diverse functions that change through development, aging and disease. This project will use statistical and machine learning approaches to tackle modeling of genome function and mutation impacts, as well as developing genome-wide models for how genes work together in biological processes and pathways in different cell contexts. 

Summer students will work with a mentor to develop and apply approaches to understand the molecular underpinnings of cell-type diversity and the impact of genetic variants in specific tissue, cell-type, and disease contexts.

Student Roles and Responsibilities: Show up on time, be courteous and respectful of all lab members and ask questions - always! Come to the lab wanting to learn and do not be afraid to ask questions and, in turn, share information with lab mates.

Students are expected to make good faith efforts at their projects. No prior experience is necessary, but an open inquisitive mind and active communication with mentors and lab members are essential. Minimal coding knowledge or better of Python or R is nice but not required. Applicants with no coding experience will be considered.

Additional Considerations: This project should require about 30 to 40 hours each week. 

Department/Institute: Genomics/ Princeton Precision Health

Participation Dates: June 25 – August 6, 2025

Stipend Offered: $0

Number of Internships Available: 0-2

Application Deadline: March 15, 2025, midnight Eastern Daylight Time